“I recently made a commitment that my wealth will be given away over the next 20 years. The majority of that funding will be spent on helping you address challenges here in Africa,” he said in an address at the African Union (AU) headquarters.
Mozambique’s former First Lady Graça Machel welcomed his announcement, saying it came in a “moment of crisis”.
“We are counting on Mr Gates’ steadfast commitment to continue walking this path of transformation alongside us,” she said.
The US government has cut aid to Africa, including programmes to treat patients with HIV/Aids, as part of US President Donald Trump’s “America First” policy, raising concerns about the future of healthcare on the continent.
Gates said his foundation, which has a long history of operating in Africa, would focus on improving primary healthcare.
“What we’ve learned is that helping the mother be healthy and have great nutrition before she gets pregnant, while she is pregnant, delivers the strongest results,” he said.
“Ensuring the child receives good nutrition in their first four years as well makes all the difference.”
In a message to young innovators, the tech billionaire noted that mobile phones had revolutionised banking in Africa, and argued that AI should now be used for the continent’s benefit.
“Africa largely skipped traditional banking and now you have a chance, as you build your next generation healthcare systems, to think about how AI is built into that,” he said.
Gates pointed to Rwanda as an example, saying it was already improving services using AI-enabled ultrasound to identify high-risk pregnancies.
The Gates Foundation said it had three priorities: ending preventable deaths of mothers and babies, ensuring the next generation grows up without having to suffer from deadly infectious diseases, and lifting millions of people out of poverty.
“At the end of 20 years, the foundation will sunset its operations,” it said in a statement.
Last month, Gates said he would accelerate his giving via his foundation.
“People will say a lot of things about me when I die, but I am determined that ‘he died rich’ will not be one of them,” he wrote in a blog post.
Giving away 99% of his fortune could still leave the fifth-richest person in the world a billionaire, according to Bloomberg.
Along with Paul Allen, Gates founded Microsoft in 1975, and the company soon became a dominant force in software and other tech industries.
Gates has gradually stepped back from the company in recent decades, resigning as its chief executive in 2000 and as chairman in 2014.
He said he had been inspired to give away money by investor Warren Buffett and other philanthropists.
However, critics of his foundation say Gates uses its charitable status to avoid tax and that it has undue influence over the global health system.
